Advanced degradable nanocellulose-based matrix for stem cell differentiation and burn wound healing - Cellu4Heal

Project summary

Rationale / Needs to be addressed: Patients with severe, life-threatening burn injuries are at risk of long-term complications and morbidity due to their extensive wounds and prolonged healing. Recent developments in regenerative medicine hold the potential of using mesenchymal stem cells (MSC) for treating these wounds. Further, an optimal delivery system for MSC therapy is urged. Objectives: Our aim is to develop and validate a novel biodegradable matrix and delivery system for MSC in treating severe burn injuries. Potential applications: Cellu4Heal matrix holds the potential for shortening the healing time of burn wounds and reducing inflammation and scar formation, reducing the patient’s susceptibility to wound infections and complications. Impact and potential benefits: Cellu4Heal matrix can aid wound healing in severe burns and reduce the related mortality and morbidity, minimize the need for repeated surgeries, and consequently impact the quality of life for these patients.