En­gi­nee­red nano-​based de­vice for glio­blas­to­ma mul­ti­for­me the­ra­py - Nano4Glio

Pro­ject sum­ma­ry

Ra­tio­na­le / Needs to be ad­dres­sed Glio­blas­to­ma (GBM) is an ag­gres­si­ve brain tu­mour that is in­cura­ble, due to drugs’ low bio­avai­la­bi­li­ty in the brain, and re­sis­tance me­cha­nisms. Other li­mi­ta­ti­ons such as high to­xi­ci­ty reen­for­ce the need for new the­ra­pies. Ob­jec­ti­ves Nano4Glio will de­ve­lop an im­plan­ta­ble de­vice com­po­sed of a bio­de­grad­able hy­dro­gel in­cor­po­ra­ting drug-​loaded na­no­par­ti­cles (NPs) for GBM con­ti­nuous tre­at­ment. Po­ten­ti­al ap­p­li­ca­ti­ons The main ap­p­li­ca­ti­on is GBM, but tre­at­ment of other neu­ro­lo­gi­cal di­sea­ses may be en­vi­sa­ged for fu­ture ap­p­li­ca­ti­ons since the NPs sur­face will be mo­di­fied with a moie­ty with af­fi­ni­ty for the brain. Im­pact and po­ten­ti­al be­ne­fits This pro­ject will de­li­ver a sui­ta­ble ap­proach to im­pro­ve GBM the­ra­peu­tic ef­fi­ca­cy, al­lo­wing for a con­ti­nuous and en­han­ced the­ra­py, wit­hout the need for daily ad­mi­nis­tra­ti­on, while over­co­ming re­sis­tance. Thus, Nano4Glio will de­li­ver a pionee­ring ap­proach that will be able to over­co­me the li­mi­ta­ti­ons of cur­rent the­ra­pies.