Biodegradable functionalized Membrane for Bone and Tissue Regeneration - Mem4BoTiReg

Project summary

The clinical need to develop a next generation of barrier membranes for active support of the bone regeneration in the alveolar ridge, that combine biocompatibility and patient-specific shape with biodegradable properties, is of great interest. This project aims to develop, characterize and investigate in vitro and in vivo a new volume-stable barrier membrane composed of the biodegradable polymer polylactic acid (PLA), functionalized with bioactive nanoparticles and the growth factor bone morphogenetic protein 2 (BMP-2). For the computer-aided 3D membranes design, exemplary Cone Beam Computed Topographical images of patients with small bone defects will be used. For the manufacturing of the membranes, both electrospinning and rapid, tomographic volumetric 3D printing were chosen. A major advantage of such membranes would be an active and specific promoting function in the regeneration processes of both bone and soft tissue as well as the exact and stable adjustment in the defect areas.