Neoteric Biomaterials for hIPSCs Monitorized Differentiation to RGCs: Creation, Microfabrication & Microfluidics - bioMAT4EYE
Project summary
Matrigel is a benchmark costly supporting material for cell culture, being a basement membrane matrix extracted from Engelbreth–Holm–Swarm murine sarcomas, presenting ethical issues, low productivity, low batch-to-batch reproducibility, and an extraordinary complex physicochemical nature. Therefore, highly reliable and tuneable materials adequate for large-scale production to replace Matrigel are desirable. bioMAT4EYE will address this need by joining several multidisciplinary research teams with key expertise in biomaterial production (fermentation, extraction), physicochemical modification and conformation in 2D, 2D+ and 3D structures by diverse technologies, micro-bioreactor design, construction and physicochemical control, and hiPSCs generation, culture and monitored differentiation to RGCs. RGCs can be the basis for cell therapies for patients with optic neuropathies of low prevalence (e.g. LHON, DOA) and age-related increasingly prevalent ones (e.g. glaucoma).Project Details
Call
Call 2021
Call Topic
New strategies for advanced material-based technologies for health applications
Project start
01.06.2022
Project end
31.05.2025
Total project costs
1.632.250 €
Total project funding
1.505.450 €
TRL
1 - 4
Coordinator
Prof. Dr. Miguel Ladero
mladerog@ucm.es
Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain
Partners and Funders Details
Consortium Partner | Country | Funder | |
---|---|---|---|
Universidad Complutense de Madrid https://www.ucm.es/ |
University | Spain | ES-AEI |
Fundación para la Investigación Biomédica del Hospital Universitario 12 de octubre https://imas12.es/ |
Other | Spain | ES-AEI |
Katholieke Universiteit Leuven https://www.kuleuven.be/kuleuven/ |
University | Belgium | BE-FWO |
RISE PFI AS https://www.rise-pfi.no/ |
Research org. | Norway | NO-RCN |
University of Ljubljana https://www.uni-lj.si/eng/ |
University | Slovenia | SI-MIZS |
Chitinor AS https://chitinor.com/ |
SME | Norway | NO-RCN |
Regemat 3D Ltd https://www.regemat3d.com/ |
SME | Spain | ES-CDTI |
Leipzig University https://www.bbz.uni-leipzig.de |
University | Germany | DE-SMWK |